It supports multiple authentication protocols including FIDO2, FIDO U2F, smart card (PIV), Yubico OTP, OpenPGP, OATH-TOTP, OATH-HOTP and Challenge-Response — all on a single device. That means it’ll work with most password managers, along with social media platforms, collaboration tools and browsers like Chrome, Firefox and Microsoft Edge.
The main difference with the latest model is that it supports both NFC and USB-C, rather than USB-A. That should work better for people with newer devices, as USB-C is now common on recent Macs, most PCs and Android smartphones. The YubiKey 5C NFC is now available for $55 on Yubico’s website.